Prior resection of glioblastoma confirmed by histology
Glioblastoma pretreated with standard radiotherapy without or with temozolomide
First progression according to RANO criteria
First progression not within 3 months after completion of radiation therapy
Complete removal of contrast-enhancing lesion considered feasible without significant risk ofpermanent speech or motor function according to MRI as confirmed by study eligibilitycommittee after screening and prior to recruitment
No encroachment of the M1 or A1 segments of the medial and anterior cerebral artery on MRI
No contrast enhancement in presumed speech and primary motor areas on MRI
No midlineshift on MRI
No contrast enhancing ventricular spread, multifocal recurrence, meningeosis carcinomatosaor infiltration of the contra-lateral hemisphere on MRI
