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- Informed consent
- ≥18 years of age
- Prior resection of glioblastoma confirmed by histology
- Glioblastoma pretreated with standard radiotherapy without or with temozolomide
- First progression according to RANO criteria
- First progression not within 3 months after completion of radiation therapy
- Complete removal of contrast-enhancing lesion considered feasible without significant risk ofpermanent speech or motor function according to MRI as confirmed by study eligibilitycommittee after screening and prior to recruitment
- No encroachment of the M1 or A1 segments of the medial and anterior cerebral artery on MRI
- No contrast enhancement in presumed speech and primary motor areas on MRI
- No midlineshift on MRI
- No contrast enhancing ventricular spread, multifocal recurrence, meningeosis carcinomatosaor infiltration of the contra-lateral hemisphere on MRI
- No contra-indication for surgery
- Good functional status (KPS ≥ 70)
